Chang, Connie

Office: 11 Chemistry/Biochemistry Bldg. (CBB)
Specialty: Drop-based microfluidics
E-mail: connie.chang@montana.edu

Dr. Connie Chang joined MSU in November 2013 from a postdoctoral position in the David Weitz laboratory at the School of Engineering and Applied Sciences, Harvard University.

Connie’s research interest is in droplet-based microfluidics, which is the creation and manipulation of tiny drops of fluid that range from picoliters to nanoliters in volume. These drops are created at rates of thousands per second and can be used in applications such as biomaterials, ultra high-throughput screening of bacterial biofilm formation, single cell genomics, and directed evolution in biology.

Chang Research Lab

Courses, Grants, Outreach

Selected Publications

Akiyama, T., Williamson, K., Schaefer, R., Pratt, S., Chang, C. B., Franklin, M. (2017) Resuscitation of Pseudomonas aeruginosa from dormancy requires hibernation promoting factor (PA4463) for ribosome preservation. Proceedings of the National Academy of Science: v. 114 i. 12 p. 3204-3209
Franklin, M., Chang, C. B., Akiyama, T., Bothner, B. (2015) New Technologies for Studying Biofilms. ASM Press, Biofilms 2nd Edition: p. 1-32
Tao, Y., Rotem, A., Zhang, H., Chang, C. B., Basu, A., Kolawole, A. O., Koehler, S. A., Ren, Y., Lin, J. S., ... , ... others, . (2015) Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics. Lab on a Chip: v. 15 i. 19 p. 3934–3940
Chang, C. B., Wilking, J., Kim, S., Shum, H. C., Weitz, D. A. (2015) Monodisperse emulsion drop microenvironments for bacterial biofilm growth. Small: v. 11 i. 32 p. 3954–3961
Zhang, H., Cockrell, S. K., Kolawole, A. O., Rotem, A., Serohijos, A. W., Chang, C. B., Tao, Y., Mehoke, T. S., Han, Y., ... , ... others, . (2015) Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics. Journal of virology: v. 89 i. 15 p. 7722–7734
Tao, Y., Rotem, A., Zhang, H., Cockrell, S. K., Koehler, S. A., Chang, C. B., Ung, L. W., Cantalupo, P. G., Ren, Y., ... , ... others, . (2015) Artifact-Free Quantification and Sequencing of Rare Recombinant Viruses by Using Drop-Based Microfluidics. ChemBioChem: v. 16 i. 15 p. 2167–2171
Audrey E Fischer, Susan K Wu, Jody BG Proescher,, ., Assaf Rotem, Connie B Chang, Huidan Zhang, Ye Tao, ., , Thomas S Mehoke, Peter M Thielen, Abimbola O, ., Kolawole, Thomas J Smith, Christiane E Wobus, David A, ., Weitz, Jeffrey S Lin, Andrew B Feldman, Joshua T, ., Wolfe, . (2015) A high-throughput drop microfluidic system for virus culture and analysis. Journal of virological methods: v. 213 p. 111–117
Chang, C. B., Knobler, C. M., Gelbart, W. M., Mason, T. G. (2008) Curvature dependence of viral protein structures on encapsidated nanoemulsion droplets. Acs Nano: v. 2 i. 2 p. 281–286
Hanson, J. A., Chang, C. B., Graves, S. M., Li, Z., Mason, T. G., Deming, T. J. (2008) Nanoscale double emulsions stabilized by single-component block copolypeptides. Nature: v. 455 i. 7209 p. 85–88